Association of antithrombin (antithrombin III) gene mutation with unexplained recurrent pregnancy loss

Background: Recurrent pregnancy loss (RPL) is an emotionally painful occurrence for couples and presents Obstetricians with a difficult clinical problem. Because primary etiology cannot be determined in roughly half of the instances, it irritating both patients obstetricians. The present study aimed to determine association antithrombin III gene (SERPINC1) mutation unexplained RPL.Methods: This case-control observational was conducted at out-patient department feto-maternal medicine, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh, total sample size 68, 34 control group case/RPL group.Results: mean±standard deviation (SD) age RPL 28.44±5.25, 29.15±4.72. mean±SD body mass index (BMI) 24.95±3.48 23.69±4.07 groups respectively. Among patients, 68% (23) had RPL, 32% (11) second loss.Conclusions: 5.88% cases have heterozygous which might cause their RPL. There no homozygous found G878A case group. allele also higher But these differences were statistically non-significant. So, clarify this further research necessary including multi-centre large sizes.